Each player loses a third of their life, then discards a third of the cards in their hand, then sacrifices a third of the creatures they control of their choice, then sacrifices a third of the lands they control of their choice. Round up each time.
Each part of Pox's effect is processed separately. For each part, first the player whose turn it is makes all necessary choices (such as which cards to discard), then each other player in turn order chooses, then the actions happen at the same time. Then Pox's effect moves to the next stage.